PMC

Proportion of patients surviving to hospital discharge (“Alive”) and proportion breathing without mechanical ventilation (“Extubated”), comparing subjects who received a diuretic during hours 48–72 after meeting ARDS criteria (solid line, “Received diuretic”) with those who did not (dotted line “No diuretic”). Time points for breathing without mechanical ventilation, represent the times of final extubation from mechanical ventilation during the study hospitalization among patients who survived to discharge. Overall, 4 patients died more than 30 days after meeting ARDS criteria, and 16 patients survived to discharge without mechanical ventilation but were extubated more than 30 days after meeting ARDS criteria

Comparison 1 Routine diuretic administration versus placebo, no treatment or PRN diuretic administration, Outcome 12 Duration of mechanical ventilation (days).

(a) Changes in areal strain for both diuretic and diabetic bladders up to 8 weeks. Unlike the diuretic group, the diabetic group demonstrated continued increase in tissue compliance at 8 weeks compare to 4 weeks. (b) Both groups exhibited a progressive and synchronous increase in mechanical anisotropy up to 4 weeks, with no further changes observed afterwards. Legend: Black circle = control bladders; white circles = diuretic bladders; black triangles = diabetic bladders. * - Significant differences (p<0.05) from controls; † - from diuretic rats of the same week; || - from 2-week diabetic bladders; and # - from 4-week diabetic bladders.

The reference groups for admission type and admission serum creatinine category were ‘Other’ category admission type and admission serum creatinine ≤ 1 mg/dL, respectively. Odds ratios were calculated from a model containing age, sex, race, comorbidities (hypertension, heart failure, CKD, diabetes and liver disease), admission type, mechanical ventilation and admission serum creatinine category.